At around 3:10 pm local time, air raid sirens sounded in the southern Jordanian city of Aqaba after ballistic missiles were launched from Iran toward the area. According to the Israeli military, the missiles were fired in the direction of Aqaba, with the Israel Defense Forces (IDF) warning that there was a possibility of spillover into Israeli territory. The IDF said sirens would be activated in Israel if necessary and noted that there were no changes to the Home Front Command's guidelines for civilians. Three missiles were reportedly intercepted by Jordanian air defense systems, while the Israeli Iron Dome system was activated in the Eilat area to deal with debris that could have posed a risk to the city. The attack came after the U.S. Embassy in Amman issued an earlier message stating that Jordanian authorities had evacuated an airport and a seaport in the country's south in response to a credible security threat. Jordanian authorities later denied that any such evacuations had taken place.

The United States carried out its eighth consecutive night of airstrikes against Iran after an Iranian ballistic missile and drone attack on a U.S. base in Jordan killed two American service members, left one missing, and wounded four others. Authorized by President Donald Trump, the operation targeted Islamic Revolutionary Guard Corps (IRGC) forces believed responsible for the Jordan attack, as well as Iranian coastal surveillance and air defense facilities aimed at reducing Iran's ability to threaten shipping through the Strait of Hormuz. US Central Command (CENTCOM) said the strikes hit military targets near Sirik on the Strait of Hormuz and Hajiabad in Hormozgan province, while Iranian state and affiliated media reported additional strikes near Shadagan (Shadegan), close to the Iraqi border, and on the Darkhovin nuclear power plant which is under construction. The Atomic Energy Organization of Iran condemned the reported strike on the Darkhovin site as a violation of international law. Explosions were also reported in Bandar Abbas and on Qeshm Island, where several locations were struck. Local media reported that a water desalination plant was hit, disrupting supplies to about 20 villages with a combined population of approximately 10,000 people. Later, the IRGC Navy claimed that two ships transiting the Strait of Hormuz had an "accident" after following an "unsafe route," while two other vessels reportedly altered their course. In response to the renewed US campaign, Iran suspended compliance with the interim ceasefire agreement reached about a month earlier and warned of further escalation. Remarks attributed to Mojtaba Khamenei described US commitments as "worthless and invalid" and threatened "unforgettable lessons" if the attacks continued. Iran's joint military command warned of a "devastating response" to additional US pressure. The collapse of the interim ceasefire has intensified missile and drone exchanges across the region, heightening concerns over broader regional instability and risks to global energy supplies. Since the war began, 16 U.S. service members have been killed and more than 430 wounded, including the two fatalities in the Jordan attack, the first direct U.S. combat deaths since the opening days of the conflict.

The United States carried out a fifth consecutive night of precision strikes against Iran, launching two waves of attacks that, for the first time in the current escalation, hit sites in the Tehran region. CENTCOM said the operation targeted command centers, air defense systems, missile and drone infrastructure, and coastal surveillance facilities, including missile storage and coastal defense systems on Greater Tunb Island, with the stated aim of reducing Iran's ability to threaten commercial shipping in the Strait of Hormuz. Iranian state media reported explosions and strikes across numerous locations, including Bandar Abbas, Tehran, Khorramabad, Khondab, Qeshm Island, Semnan Airport, Isfahan, Ahvaz, Bushehr, Chabahar, and many other southern and inland sites, along with damage to an industrial facility. American forces also disabled a Curaçao-flagged oil tanker with Hellfire missiles after it attempted to reach Kharg Island in defiance of the naval blockade on Iranian ports. Iran's army reported at least seven active-duty and conscript personnel killed, while Iranian health officials said at least 35 people were killed and 300 wounded over the preceding week of strikes; these figures have not been independently verified by Western outlets. In retaliation, the IRGC launched missile and drone attacks on US military targets in Bahrain, Kuwait, and Jordan, injuring Kuwaiti military personnel, while Qatar and the UAE intercepted incoming projectiles. Iran also warned that further regional infrastructure could be targeted. The IRGC declared the Strait of Hormuz closed "until the end of America's evils" and threatened to shut off additional oil and gas export routes serving US and allied interests. The renewed fighting followed the collapse of a recent ceasefire, which Iran said the US had disregarded from the outset, and further undermined an earlier memorandum meant to revive nuclear negotiations. Foreign Ministry spokesman Esmaeil Baghaei said Iran had no current plans for talks and would not honor any agreement if the US "breaches its obligations," while President Donald Trump said Iran was nonetheless seeking negotiations, warned that further strikes, including on nuclear facilities, remained possible, and called Iran's release of an American detainee a positive gesture despite the ongoing conflict.

At around 10:57 am local time, two explosive devices went off near the Four Seasons Hotel in Damascus, where French President Emmanuel Macron was staying during his state visit. The hotel is located near the Ministry of Tourism and the Damascus National Museum on a busy street in the capital, though the blasts took place on a peripheral road not far from the hotel. According to Syrian officials, one of the devices was placed in a garbage bin and the other in a parked car. At least eighteen people were wounded in the blasts, including four police officers. A van and a motorcycle caught fire, but otherwise the damage was relatively low. It remains unclear whether the devices were specifically targeting Macron's convoy as he made his way to the presidential palace to meet Syrian President Ahmed al-Sharaa, though the apparent aim was to create unrest by undermining the visit and casting doubt on Syria's security situation at a sensitive moment for the country's transitional government. Roads were sealed off and security measures were put in place following the explosions. No group has immediately claimed responsibility for the attack, which was likely carried out by an Islamic State (IS) cell.

An IED explosion at a crowded café near the Palace of Justice in central Damascus killed at least five people and injured 16 others. Though no group has immediately claimed responsibility for the attack, security officials blamed Islamic State sleeper cells for the bombing. Damascus has experienced only a small number of attacks since the fall of the Assad government in December 2024, when President Bashar al-Assad fled to Moscow after rebel forces led by President Ahmed al-Sharaa captured the capital, bringing an end to more than 14 years of civil war and the Assad family's 54-year rule. On 19 May 2026, a car bomb outside the Ministry of Defense in Damascus killed one Syrian soldier and injured at least 18 other people.